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ID de Correlação:9af0e5ae-b48d-4916-b929-ffe358693b0d


Artigos em revistas ► internacionais com arbitragem

 

Referência Bibliográfica


LINHARES, D., GARCIA, P.V., SILVA, C., BARROSO, J., KAZACHKOVA, N., PEREIRA, R., LIMA, M., CAMARINHO, R., FERREIRA, T., RODRIGUES, A. (2016) - DNA damage in oral epithelial cells of individuals chronically exposed to indoor radon (222Rn) in a hydrothermal area. Environmental Geochemistry and Health, doi: 10.1007/s10653-016-9893-2.


Resumo


​Hydrothermal areas are potentially hazardous to humans as volcanic gases such as radon (222Rn) are continuously released from soil diffuse degassing. Exposure to radon is estimated to be the second leading cause of lung cancer, but little is known about radon health-associated risks in hydrothermal regions. This cross-sectional study was designed to evaluate the DNA damage in the buccal epithelial cells of individuals chronically exposed to indoor radon in a volcanic area (Furnas volcano, Azores, Portugal) with a hydrothermal system. Buccal epithelial cells were collected from 33 individuals inhabiting the hydrothermal area (Ribeira Quente village) and from 49 individuals inhabiting a nonhydrothermal area (Ponta Delgada city). Indoor radon  was measured with Ramon 2.2 detectors. Chromosome damage was measured by micronucleus cytome assay, and RAPD-PCR was used as a complementary tool to evaluate DNA damage, using three 10-mer primers (D11, F1 and F12). Indoor radon concentration correlated positively with the frequency of micronucleated cells (rs = 0.325, p = 0.003). Exposure to radon is a risk factor for the occurrence micronucleated cells in the inhabitants of the hydrothermal area (RR = 1.71; 95% CI, 1.2–2.4; p = 0.003). One RAPD-PCR primer (F12) produced differences in the banding pattern, a fact that can indicate its potential for detecting radon-induced specific genomic alterations. The observed association between chronic exposure to indoor radon and the occurrence of chromosome damage in human oral epithelial cells evidences the usefulness of biological surveillance to assess mutations involved in precarcinogenesis in hydrothermal areas, reinforcing the need for further studies with human populations living in these areas.

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